Nobel Prize Discovery May Help Cancer Treatment in Dogs–and Humans

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298 – The Annual, 2022-23

By Caroline Coile

Now a researcher at the University of Missouri (MU) College of Veterinary Medicine used the technique to treat osteosarcoma in dogs—the first time the procedure has been successful in any animal larger than a mouse.

The problem in using an antibody to deliver chemotherapy drugs or radioactive materials to a tumor is that much of these therapies often affect the rest of the body as much or more as the tumor. With click chemistry much more of the therapeutic materials are delivered directly to the tumor. But until now, it was thought it could only work in very small animals because two opposing parts of the therapy-delivering molecules may have difficulty finding each other in a large animals, including humans, in order to “click” together.

MU veterinary oncologist Jeffry Bryan used the technique work in 100-pound-plus dogs with osteosarcoma. Osteosarcoma is a common form of bone cancer that is difficult to treat, in part because additional bone tumors are often hiding in the dog’s skeleton. With click therapeutics these hidden nodules are also targeted.

In this preliminary study five dogs were given the click treatment. Subsequent PET scans showed that the therapeutic drugs and radioactive treatments targeted the bone tumors and no other parts of the body except for the bladder and kidney (because the excess radioactive component is excreted through the kidneys). No adverse effects were noted. It is too early to know if the treatment was successful in fighting the tumors, but it was definitely successful in delivering targeted therapy.

 Click here to read the complete article
298 – The Annual, 2022-23

Short URL: https://caninechronicle.com/?p=254311

Posted by AnthonyA on Jan 8 2023. Filed under Current Articles, Featured. You can follow any responses to this entry through the RSS 2.0. Both comments and pings are currently closed.