New DNA Testing Scheme to Combat Inherited Disease in the ‘Vulnerable’ Otterhound

Photo credit: Marc Henrie / The Kennel Club

In a move designed to combat inherited disease in the Otterhound, the Kennel Club has approved a new official DNA testing scheme for Glanzmann’s Thrombasthenia in the breed, following consultation with the Breed Health Coordinator.

The Otterhound is a Kennel Club Vulnerable British Breed, a category for breeds which generate 300 or fewer registrations in a year. In fact, a mere 44 Otterhound puppies were registered in 2019, with none so far in 2020, making them among the rarest British breeds of all.

Glanzmann’s Thrombasthenia is an inherited condition that causes affected dogs to have problems with their blood-clotting ability. Dogs usually show signs before they are a year old, often by bleeding from the gums as their adult teeth come through. Warning signs can include bruising easily, frequently bleeding from the nose, blood in their urine, or their stools may be red with fresh blood or black and tarry from old blood.

The disease is described as an autosomal-recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Tested dogs will be recorded on the Kennel Club systems as one of the following:

Clear

The dog does not have any copies of the abnormal gene associated with Glanzmann’s Thrombasthenia. The dog is highly unlikely to be clinically affected and will pass on only a normal copy of the gene to a puppy.

Carrier

The dog has one copy of the normal gene and one copy of the abnormal gene associated with Glanzmann’s Thrombasthenia. The dog is unlikely to be clinically affected but may pass on one copy of the normal gene, or one copy of the abnormal gene, to a puppy.

Affected

The dog has two copies of the abnormal gene associated with Glanzmann’s Thrombasthenia. The dog will be clinically affected by the disorder and will pass on one copy of the abnormal gene to any potential offspring.

Judith Ashworth, Otterhound Breed Health Coordinator, said: “The Otterhound is basically a very healthy breed. However, as their numbers are very low, breeders need every assistance they can get when it comes to ensuring the breed is preserved for future generations, partly through breeding interaction across the world. To protect UK Otterhounds from a new condition is why this DNA testing scheme is such good news – when taken into account with other factors, it will enable breeders to make more informed choices when deciding to breed a litter.”

To find out which laboratories the Kennel Club is able to record results from, and which labs will send results direct to the Kennel Club, please refer to the worldwide DNA testing list at www.thekennelclub.org.uk/worldwide-dna-tests. Please note that this listing is not necessarily comprehensive and other labs may offer the tests.

The Kennel Club constantly reviews DNA testing schemes in conjunction with breed clubs to ensure that breeders are supported with resources which help them to make responsible breeding decisions.

The Kennel Club works alongside breed clubs and breed health coordinators in a collaborative effort to improve the health of pedigree dogs and is happy to accommodate a club’s request to add a new DNA test to its lists. A formal request from the breed’s health coordinator or a majority request from the breed clubs is normally required to do this.

Test results will be added to the dog’s registration details which will trigger the publication of the result in the next available Breed Records Supplement. The result will appear on any new registration certificate issued for the dog and on the registration certificates of any future progeny of the dog, and also on the Health Test Results Finder on the Kennel Club website.

Results for dogs already tested can also be recorded, but owners will need to submit copies of the DNA certificates themselves. If the owner includes the original registration certificate for the dog (not a copy) then a new registration certificate will be issued, with the DNA result on it, free of charge. DNA test certificates should be emailed to health.results@thekennelclub.org.uk.

Owners are reminded that it is mandatory that the dog’s microchip (or tattoo) number is recorded along with either the dog’s registered name or registered number on any DNA certificates. Any test results that do not carry these identifying features will not be added to the Kennel Club database.

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Posted by chesliepickett on Apr 30 2020. Filed under World News. You can follow any responses to this entry through the RSS 2.0. Both comments and pings are currently closed.